• Users Online: 314
  • Print this page
  • Email this page

 Table of Contents  
Year : 2022  |  Volume : 60  |  Issue : 1  |  Page : 132

Role of eye changes in diagnosis of systemic diseases

Department of Neurology, Dr. S.N. Medical College, Jodhpur, Rajasthan, India

Date of Submission15-Sep-2020
Date of Acceptance28-Sep-2021
Date of Web Publication22-Mar-2022

Correspondence Address:
Dr. Khichar Shubhakaran
House No. E-22/13, Umed Hospital Campus, Opposite Geeta Bhavan, Jodhpur - 342 003, Rajasthan
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/tjosr.tjosr_136_20

Rights and Permissions

How to cite this article:
Shubhakaran K. Role of eye changes in diagnosis of systemic diseases. TNOA J Ophthalmic Sci Res 2022;60:132

How to cite this URL:
Shubhakaran K. Role of eye changes in diagnosis of systemic diseases. TNOA J Ophthalmic Sci Res [serial online] 2022 [cited 2022 Jun 29];60:132. Available from: https://www.tnoajosr.com/text.asp?2022/60/1/132/340349

I read an interesting imaging of Roth spots by Mohan and Rajan published in September 2020 issue (213-4).[1] The authors have highlighted the importance of such finding in clinching to a diagnoses such as bacterial endocarditis, leukemia, and anemia.[1] Here I would like to share my experience and views as under:

  1. Certain eye changes are well documented and are of diagnostic like in bacterial endocarditis, congenital, and hereditary metabolic disorders.[2] They are also being described in certain infectious diseases such as malaria, dengue, HIV, and cysticercosis.,[2],[3] where in these require to be established as a diagnostic marker in further prospective and retrospective studied
  2. We studied the ophthalmoscopic abnormalities in adult patients of falciparum malaria and concluded that the ophthalmoscopic abnormalities in malaria had no statistically significant association with poor prognosis except disc pallor, but the patients with ophthalmoscopic abnormalities have a trend of worse prognosis in comparison to those without the changes. We also concluded by analyzing our data that the ophthalmoscopic changes were the reflection of underlying organ dysfunctions such as anemia and renal failure.[3] as the authors pointed out anemia and leukemia[1]
  3. Similarly, various such eye changes such as Roth spot and other changes were also reported in dengue patients.[2]
  4. We also found a patient of malaria with vitreous haemorrhage who presented with visual deterioration before losing consciousness so it may be reason of visual impairment in patients of malaria besides optic neuritis acute disseminated encephalomyelitis and cortical blindness[4]
  5. The detection of such changes is an important bedside tool which help diagnose, narrow down the differentials in a particular clinical setting, i.e. in malaria and dengue in an endemic area, especially with flare up during particular seasons and prognosis.[2],[4],[5]

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

  References Top

Mohan S, Rajan M. Roth spots; a window to underlying conditions. TNOA J Ophthalmic Sci Res 2020;58:231-4.  Back to cited text no. 1
Shubhakaran K, Khichar RJ. Nonmydriatic ocular fundus photography among headache patients in an emergency department. Neurology Oct 2013;81(15):1366-1367. doi: 10.1212/01.wnl.000043684.64959.67.  Back to cited text no. 2
Mehta S. Ocular lesions in severe dengue hemorrhagic fever (DHF). J Assoc Physicians India 2005;53:656-7.  Back to cited text no. 3
Kochar DK, Shubhakaran, Kumawat BL, Thanvi I, Joshi A, Vyas SP. Ophthalmoscopic abnormalities in adults with falciparum malaria. QJM 1998;91:845-52.  Back to cited text no. 4
Kochar DK, Shubhakaran, Kumawat BL, Vyas SP. Prognostic significance of eye changes in cerebral malaria. J Assoc Physicians India 2000;48:473-7.  Back to cited text no. 5


Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

  In this article

 Article Access Statistics
    PDF Downloaded23    
    Comments [Add]    

Recommend this journal