• Users Online: 912
  • Print this page
  • Email this page


 
 Table of Contents  
OPHTHALMIC IMAGE
Year : 2022  |  Volume : 60  |  Issue : 4  |  Page : 330

Chlorpromazine-Induced cataract and corneal pigmentation


Department of General Ophthalmology, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Tirunelveli, Tamil Nadu, India

Date of Submission09-Jul-2022
Date of Decision27-Jul-2022
Date of Acceptance15-Aug-2022
Date of Web Publication19-Dec-2022

Correspondence Address:
Sarvesswaran Prakash
Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Tirunelveli, Tamil Nadu
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/tjosr.tjosr_60_22

Rights and Permissions

How to cite this article:
Prakash S. Chlorpromazine-Induced cataract and corneal pigmentation. TNOA J Ophthalmic Sci Res 2022;60:330

How to cite this URL:
Prakash S. Chlorpromazine-Induced cataract and corneal pigmentation. TNOA J Ophthalmic Sci Res [serial online] 2022 [cited 2023 Feb 8];60:330. Available from: https://www.tnoajosr.com/text.asp?2022/60/4/334/364253



Chlorpromazine is used in treating schizophrenia but on long-term usage can cause irreversible ocular toxicity affecting the cornea, conjunctiva, and lens.[1] It is hypothesised that phenothiazines denature proteins when exposed to light; the proteins then become opacified and are deposited in ocular tissues.[2],[3],[4],[5] Herewith, we report a 54-year-old chronic schizophrenia patient who was treated with chlorpromazine hydrochloride 300 mg/d for the past 15 years. On examination, the visual acuity was 6/9 in both eyes. On slit lamp examination, both eyes revealed discrete yellow refractile deposits on the corneal stroma and characteristic bilateral stellate-shaped anterior sub-capsular cataract [Figure 1]. Fundus examination was normal in both eyes.
Figure 1: Slit lamp photographs show yellowish stellate-shaped characteristic anterior sub-capsular cataract in the right eye (a), left eye (b), and fine discrete yellow refractile deposits in the posterior stroma in the right eye (c) and left eye (d)

Click here to view


Declaration of patient consent

The authors certify that they have obtained all appropriate patient consents forms. In the form patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Greiner AC, Berry K. Skin pigmentation and corneal and lens opacitieswith prolonged chlorpromazine therapy. Can Med Assoc J 1964;90:663-5.  Back to cited text no. 1
    
2.
Howard RO, McDonald CJ, Dunn B, Creasey WA. Experimental chlorpromazine cataracts. Invest Ophthalmol 1969;8:413-21.  Back to cited text no. 2
    
3.
Deluise VP, Flynn JT. Asymmetric anterior segment changes induced by chlorpromazine. Ann Ophthalmol 1981;13:953-5.  Back to cited text no. 3
    
4.
Siddall JR. The ocular toxic findings with prolonged and high dosage chlorpromazine intake. Arch Ophthalmol 1965;74:460-4.  Back to cited text no. 4
    
5.
Webber SK, Domniz Y, Sutton GL, Rogers CM, Lawless MA. Corneal deposition after high-dose chlorpromazine hydrochloride therapy. Cornea 2001;20:217-9.  Back to cited text no. 5
    


    Figures

  [Figure 1]



 

Top
 
 
  Search
 
Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

 
  In this article
References
Article Figures

 Article Access Statistics
    Viewed188    
    Printed12    
    Emailed0    
    PDF Downloaded20    
    Comments [Add]    

Recommend this journal


[TAG2]
[TAG3]
[TAG4]